2024 Fall Co-op - Data and Computational Science, mRNA Center of Excellence, Sanofi - Vaccines

Sanofi

Mar 27

Applications are closed

Internship
Full-time
Off-cycle Internship
Science
Engineering
Waltham

Requirements

Basic Qualifications:
Currently enrolled in a biology, chemical or biochemical engineering, or equivalent program and working toward BS, MS, or PhD degree program
Preferred Qualifications:
Basic understanding of mRNA technology
Knowledge in enzymatic reactions such as in vitro- transcription, capping and tailing
Experience in First principle and hybrid dynamic modeling, and model-based DoE
Familiar with mathematical software and packages (Python, Julia, MATLAB, PYOMO, sklearn, gPROMS)

Responsibilities

The Co-op position is based in the Data and Computational Science (DCS) department within the Sanofi mRNA Center of Excellence (mRNA CoE) supporting the activities in the CMC data science group. This position will focus on In Vitro Transcription (IVT) modelling, Model-based Design of Experiments (MBDoE), advanced process control (APC), machine learning and data visualization, supporting the main functions in the CMC data science team. The candidate will have opportunities to learn about mRNA technology, unit operations and to demonstrate the benefits of process modeling and advanced control in a non-GMP lab environment.
The successful candidate will work with his/her supervisor to develop dynamic models for In Vitro Transcription (IVT) reactions. The activities include to investigate how process parameter influence product quality attributes and uncertainty quantification, design model-based DoE for model structure selection and parameter optimization, and scalability and robustness analysis of the developed models.

Sanofi

Science & Healthcare

Industry

10,001+

Employees

2004

Founded Year

Mission & Purpose

We are Sanofi, an innovative global healthcare company. We chase the miracles of science to improve people’s lives. Our team, across some 100 countries, is dedicated to transforming the practice of medicine by working to turn the impossible into the possible. We provide potentially life-changing treatment options and life-saving vaccine protection to millions of people globally, while putting sustainability and social responsibility at the center of our ambitions.