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2024 QTAS Biologics Bioanalysis Characterization and Disposition Intern

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AbbVie

Mar 22

Applications are closed

  • Internship
    Full-time
    Summer Internship
  • Science
  • $51.5K - $98K
  • San Francisco

Requirements

  • Minimum Qualifications:
  • Currently enrolled in a Master's or PhD program in Analytical Chemistry, Biochemistry, Pharmaceutical Science, or related field.
  • Must be enrolled as a student for the duration of the internship period.
  • Hands-on experience with LC-MS instrumentation.
  • Preferred Qualifications:
  • Expected graduation date between December 2024 – July 2025.
  • Ability to conduct, troubleshoot, and interpret scientific experiments, providing suggestions for additional experiments, including design and development of new LC-MS assays, especially related to bioanalysis.
  • Demonstrate critical thinking and problem-solving skills, including data analysis.
  • Self-motivated; ability to execute with limited supervision and direction. Can work independently or part of a team.
  • Proficient in productivity & data analysis software including Microsoft Office Suite, GraphPad Prism, Sciex OS.
  • Familiarity with Shimadzu UPLC, Waters M-Class, and SCIEX QQQ.
  • Fundamental understanding of protein therapeutics (mAbs, ADCs, multispecifics, etc.) and DMPK principles.

Responsibilities

  • Set up initial microflow LC-MS/MS method for protein quantitation.
  • Optimize direct injection method and trap-elute method.
  • Adjust the sample preparation workflow to improve compatibility with microflow assay.
  • Identify the most suitable trap and analytical column combinations for the workflow.
  • Evaluate microflow assay robustness and sensitivity and compare to the analytical flow assay.
  • Draft protocols for optimized methods.
  • Present work (oral presentation and/or poster) to the broader department.

AbbVie

Science & Healthcare
Industry
10,001+
Employees

Mission & Purpose

AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.