Co-op Student, Medicinal Chemistry

Zymeworks Inc.

2mo ago

Applications are closed

Internship
Full-time
Off-cycle Internship
Research & Development
Science
Vancouver

Requirements

Education and Experience:
Currently enrolled in an undergraduate program in Chemistry and successful completion of Organic Chemistry courses (2nd Year) with lab.
Availability for an 8-month co-op term is required.
Experience with multi-step synthetic chemistry over and above the teaching lab is preferred
Skills and Abilities:
Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
Good organizational skills and the ability to work effectively in a high-paced, fast-changing environment. Results-oriented mindset
Experience with multi-step synthetic chemistry over and above the teaching lab is required
Experience with characterization of small molecules using NMR and HPLC-MS and some familiarity with operating these instruments outside of the teaching lab is preferred.
Excellent oral and written communication capabilities
Good computer skills particularly with MS Office suite and ChemOffice (ChemDraw)

Responsibilities

The student is expected to participate in the generation of new drugs and drug-linkers for evaluation as potential antibody-drug conjugate platform technologies:
Reproduces or adapts established synthetic procedures to transform chemical species into target payloads, intermediates, and drug-linkers
Monitors reaction progress using HPLC-MS and TLC
Uses appropriate purification techniques (wet work-up, flash chromatography, prep-HPLC-MS) to isolate desired chemical products
Characterizes isolated materials to confirm structure and purity (NMR, HPLC-MS)
Performs experiments, interprets, and analyzes data, and prepares presentations for group meetings
Administrative duties such as contributing to the chemical inventory system
Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks policies and practices
Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic notebook
Contributes to a safe and highly efficient laboratory environment through ordering of consumables, regular maintenance of reagent inventory, preparation of solutions, stocking of consumables, and maintaining a clean working environment

Zymeworks Inc.

Developing novel medicines for patients with difficult-to-treat cancers and other serious diseases.

Science & Healthcare

Industry

201-500

Employees

2003

Founded Year

Mission & Purpose

Zymeworks (NASDAQ:ZYME) is a clinical-stage biopharmaceutical company dedicated to the development of next-generation multifunctional biotherapeutics. Zymeworks’ suite of therapeutic platforms and its fully integrated drug development engine enable precise engineering of highly differentiated product candidates. Zymeworks’ lead clinical candidate, zanidatamab, is a novel Azymetric™ HER2-targeted bispecific antibody currently being evaluated in multiple Phase 1, Phase 2, and pivotal clinical trials globally as a targeted treatment option for patients with solid tumors that express HER2. Zymeworks’ second product candidate, Zanidatamab Zovodotin (ZW49), is a bispecific antibody-drug conjugate currently in Phase 1 clinical development and combines the unique design and antibody framework of zanidatamab with Zymeworks’ proprietary ZymeLink™ linker-cytotoxin. Zymeworks is also advancing a deep preclinical pipeline in oncology (including immuno-oncology agents) and other therapeutic areas. In addition, its therapeutic platforms are being leveraged through strategic partnerships with nine biopharmaceutical companies.