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Scientist I, Biologics Drug Product Development

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AbbVie

4d ago

  • Job
    Full-time
    Junior, Mid & Senior Level
  • Science
    Research & Development
  • North Chicago

AI generated summary

  • You need a relevant degree, 2-5 years in pharma, protein biochemistry knowledge, biologics formulation experience, hands-on analytical skills, strong communication, and familiarity with cGMP.
  • You will design and execute experiments, analyze data, support project timelines, learn new techniques, and maintain detailed lab notes and reports to drive drug development projects.

Requirements

  • Bachelor’s Degree or equivalent education in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical science, or a related field with 5+ years of pharmaceutical industry experience, or Master’s Degree or equivalent education with 2+ years of experience.
  • Theoretical and practical knowledge of protein biochemistry, stability, and analytics.
  • Experience with biologics (proteins, conjugates, peptides and/or neurotoxins) and/or genetic medicine (AAV, LNPs, cell therapy) formulation development, in-use studies, and DP process development.
  • Hands-on experience with biologics or genetic drug product preparation and analysis, e.g. HPLC/UPLC, UV-Vis spectroscopy, etc.
  • Excellent communication and written skills.
  • Familiarity with analytical techniques for protein stability and characterization testing, including SEC, CE-SDS, icIEF, HIAC, MFI, DLS, DSC, etc.
  • Knowledge of Design of Experiment (DoE), data analysis and experience of statistical software packages is preferred.
  • Understanding of relevant cGMP and regulatory guidance.
  • Experience with sterile manufacturing unit operations (freeze-thaw, mixing, filtration, filling, and freeze-drying) development and characterization.
  • Ability to multitask and meet timelines in a dynamic environment.

Responsibilities

  • Independently execute and interpret critical experiments to answer scientific questions related to pharmaceutical development activities. Understand the broad objectives of the project as well as their role in achieving those objectives and modify experimental plan when required.
  • Meet experimental and project timelines in accordance with CMC strategy.
  • Support development projects with hands-on laboratory experimentation, data generation, and analysis of results. As needed, provide support for technical transfer and scale-up of laboratory process knowledge to manufacturing sites.
  • Learn and understand new experimental techniques and develop proficiency in techniques to serve as a resource for others.
  • Maintain detailed and organized electronic laboratory notebook, and compile data into scientific presentations and reports to support project goals.

FAQs

What is the primary focus of the Scientist I, Biologics Drug Product Development position?

The primary focus is on drug product formulation and process development for biologics and genetic medicine, including execution of laboratory experiments and collaboration with cross-functional groups.

What qualifications are required for this position?

A Bachelor’s Degree or equivalent in a relevant field with 5+ years of pharmaceutical industry experience, or a Master’s Degree with 2+ years of experience, along with knowledge of protein biochemistry and biologics formulation development.

What types of experimental techniques should a candidate be familiar with?

Candidates should have hands-on experience with techniques such as HPLC/UPLC, UV-Vis spectroscopy, and familiarity with analytical techniques like SEC, CE-SDS, and DLS.

Is experience with regulatory guidance necessary for this role?

Yes, an understanding of relevant cGMP and regulatory guidance is necessary for the position.

Will the candidate need to work with cross-functional teams?

Yes, effective collaboration with cross-functional groups to support project goals is a key responsibility of this role.

What is the expected work environment for this position?

The work environment is dynamic, requiring the ability to multitask and meet project timelines while maintaining organized laboratory documentation.

What benefits does AbbVie offer for this position?

AbbVie offers a comprehensive package of benefits including paid time off, medical/dental/vision insurance, 401(k), and eligibility to participate in short-term incentive programs.

How does AbbVie ensure diversity and inclusion in its hiring process?

AbbVie is committed to employing qualified persons without discrimination against any legally protected status and emphasizes driving innovation and serving the community.

Will the candidate need to maintain a laboratory notebook?

Yes, maintaining a detailed and organized electronic laboratory notebook is a key responsibility of the position.

What kind of projects will the candidate support?

The candidate will support development projects through hands-on laboratory experimentation, data generation, and analysis of results.

Science & Healthcare
Industry
10,001+
Employees

Mission & Purpose

AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.