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Scientist II, Protein Biology

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Thermo Fisher Scientific

10d ago

  • Job
    Full-time
    Mid, Senior & Expert Level
  • Science
    Research & Development

AI generated summary

  • You need a PhD plus 2-4 years or a Master's with 5-10 years in life sciences, strong flow cytometry skills, experience in molecular biology, immunoassays, and leadership. GLP experience is essential.
  • You will lead antibody development projects, mentor junior scientists, execute experiments, drive protocol ideation, provide technical guidance, and support commercialization and manufacturing efforts.

Requirements

  • PhD with 2 to 4 years' experience, or
  • Masters degree with 5 to 10 years' experience
  • Min 3-4 years of Industrial experience is required
  • Applicants should have a degree in a relevant life sciences field with a strong focus on sophisticated flow cytometry, cell sorting, panel design and immunology.
  • Strong background in flow cytometry including single cell sorting, immunophenotyping, multicolor flow cytometry and panel design, rare population analysis
  • Hands-on experience with both intracellular and extracellular multi-color staining
  • Understanding of cytometry data analysis techniques (e.g. population gating, compensation, etc.)
  • Proficiency with flow cytometry analysis software (e.g. FlowJo, FCS Express)
  • Ability to process tissue and isolate cells, particularly human/mammalian PBMCs and mouse splenocytes
  • Solid understanding and hands on experience with monoclonal antibody development methods using one or more of the following technologies would be an advantage: single B cell sorting, phage display, recombinant technology
  • Experience in preparing and culturing human and mouse primary immune cells
  • Proficient in molecular biology workflows such as high-throughput molecular cloning, plasmid vector construction, PCRs, Restriction digestion, Ligation, Transformation, Mini and maxi preps, sequencing
  • Thorough in biochemical and immunoassay workflows such as recombinant protein expression and purification, ELISA, SDS-PAGE, Western blotting, IF, IHC
  • Working knowledge of fluorescence microscopy, fluorescence detection technologies is helpful
  • Experience in authoring and optimizing standard operating procedures with a focus on reproducibility
  • Interest in identifying deviations from expected outcomes, fixing and suggesting alternatives
  • Excellent written and verbal presentation skills
  • Proven leadership skills and ability to work alongside colleagues from different backgrounds
  • Ability to succeed with a moderate level of supervision and guidance
  • Ability to provide technical trouble shooting to resolve scientific problems.
  • Proficient in software or platforms for molecular biology and sequence analysis, MS Office and statistical software such as GraphPad Prism.
  • Authorship of peer-reviewed publications with post-doctoral experience and a strong, independent understanding of standard and emerging research protocols and techniques are preferred. GLP experience is a must.
  • Prior project leadership experience preferred.

Responsibilities

  • Contribute in a fast-paced environment towards Antibody development & Validation
  • Project leadership role in new antibody development programs with vast experience in experimental planning and execution to meet the program objectives.
  • Lead team of scientists in matrix style operation, provide technical and operational supervision. Mentoring and training junior scientists in research,
  • Design and experimental execution, interpreting data and data presentation to the stakeholders.
  • Drive ideation within teams to enable development of successful protocols for effective transfer to operation teams.
  • Serve as domain expert in the field of flow cytometry, cell sorting and protein biology to provide inputs and guidance towards driving innovation and cross team collaborations.
  • Knowledge of product commercialization processes from concept to launch including early feasibility, development, and validation phases.
  • Support manufacturing team for technical support and quality by providing technical guidance.

FAQs

What is the work schedule for the Scientist II, Protein Biology position?

The work schedule for this position is classified as "Other," which typically indicates that it may require flexibility in hours and is not limited to standard office hours.

What kind of environment will I be working in?

You will be working in an office environment, which involves collaborative work with the antibody development team.

What qualifications are necessary for this position?

Applicants should possess either a PhD with 2 to 4 years of experience, or a Master's degree with 5 to 10 years of experience, along with a minimum of 3-4 years of industrial experience.

What specific skills are required for this role?

A strong background in flow cytometry, cell sorting, immunology, and experience in molecular biology workflows, antibody development, and biochemistry is required. Proficiency in flow cytometry analysis software and familiarity with techniques like ELISA, SDS-PAGE, and Western blotting are also essential.

Will I be leading a team in this role?

Yes, you will play a project leadership role in new antibody development programs and lead a team of scientists while providing technical and operational supervision.

Is prior experience in project leadership preferred?

Yes, prior project leadership experience is preferred for this position.

Are there opportunities for mentorship in this role?

Yes, you will be responsible for mentoring and training junior scientists in research and experimental execution.

What kind of career development opportunities does Thermo Fisher Scientific offer?

Thermo Fisher Scientific offers outstanding career and development prospects, as well as a supportive company culture that emphasizes innovation and growth.

Is experience with GLP (Good Laboratory Practice) required?

Yes, GLP experience is required for applicants.

Are there benefits associated with this position?

Yes, Thermo Fisher Scientific offers competitive remuneration, an annual incentive plan bonus, healthcare, and a range of employee benefits.

Thermo Fisher Scientific

The World Leader In Serving Science

Science & Healthcare
Industry
10,001+
Employees

Mission & Purpose

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.