DMPK & M PhD Internship - Summer 2024

Takeda

Jan 26

Applications are closed

Internship
Full-time
Summer Internship
Data
Science
Boston

Requirements

Exceptional interpersonal, verbal communication and writing skills.
Deadline-driven with an elevated level of organizational and planning skills.
Strong quantitative, analytical, problem solving and conceptual skills.
Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity.
Global mindset to grow in a diverse work environment.
Requirements / Qualifications:
Graduate student pursuing Ph.D. (with 0+ years industry experience) in good academic standing with a major in drug metabolism and pharmacokinetics, clinical pharmacology, pharmaceutical sciences, bioengineering, biology, mathematics, biochemistry, pharmacology, or related fields
Graduate, PhD, MD student with completion of a minimum of one year of university studies.
Prior experience in PBPK or other PK based modeling, good understanding of general pharmacokinetic principles and disposition of small molecules and/or biologics
Ability to write differential equations for physiological systems
Proficient in one or more of the following modeling and simulation software – Matlab and/or Simbiology (preferred), R, Phoenix, Berkley Madonna, ADAPT, Mathematica or other relevant software
Exceptional interpersonal, verbal communication and writing skills.
Deadline-driven with an elevated level of organizational and planning skills.
Strong quantitative, analytical, problem solving and conceptual skills.
Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity.
Global mindset to grow in a diverse work environment.
Currently authorized to work in the United States without sponsorship. Takeda does not provide sponsorship for internship positions.
Available to work full-time (40 hours per week), within the core business hours of 8:00am – 5:00pm, for 10-12 weeks during the summer months.
Must be enrolled in school the semester following your internship with Takeda.

Responsibilities

As an intern in the DMPK & M department, the candidate will be responsible for design and implementation of physiologically based pharmacokinetic (PBPK) models for biologics supporting discovery and development programs and will be involved in communication with multi-functional teams. The project accountabilities include but are not limited to –
Develop the basic PBPK framework for preclinical species and humans in Matlab, Phoenix or other relevant software for biologics
Apply the models for evaluating the impact of target mediated drug disposition, prediction of tissue exposure to inform safety margins, predict the dynamics and PK changes in diseased state
How you will contribute:
You will be involved in building a simulations-based platform for these modalities for quantitative translation from preclinical species to humans by collaborating with internal as well as external resources. You will work closely with project teams and other functional group colleagues for the supporting activities. Broadly, you will learn to apply PBPK modeling and simulation to solve real-world problems. Specifically, you will learn how to develop and apply the learnings from physiological modeling for better tissue exposure and dose prediction in preclinical species, extrapolate this information for prediction of human PK and build models to predict PK in diseased state.

Takeda

Better Health, Brighter Future

Science & Healthcare

Industry

10,001+

Employees

Mission & Purpose

We strive to transform lives. While the science we advance is constantly evolving, our core purpose is enduring. For more than two centuries, our values have guided us to do what’s right for patients and for society. We know that changing lives requires us to do things differently. We start by listening to and addressing what really matters to patients, the people who love them, and those in the healthcare system who provide care. And that’s what inspires us all to be bold, push boundaries and set new standards that open up greater opportunities.