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Summer 2025 - Computational Biology Internship

  • Internship
    Full-time
    Off-cycle Internship
  • Data
    Research & Development
  • Seattle
  • Quick Apply

AI generated summary

  • You need proficiency in R, familiarity with single-cell RNA sequencing, data visualization experience (ggplot2, Plotly), strong analytical skills, and effective communication abilities.
  • You will develop automated QC pipelines, conduct comparative data analysis, generate reports, and create interactive visualization tools to display cell type projections and mapping scores.

Requirements

  • Proficiency in R programming language.
  • Familiarity with single-cell RNA sequencing data analysis methods.
  • Experience with data visualization libraries (e.g., ggplot2, Plotly).
  • Ability to work with bioinformatics tools and packages, particularly those used for single cell analysis.
  • Strong analytical and problem-solving skills.
  • Excellent communication and documentation skills.
  • Ability to work independently and as part of a team.

Responsibilities

  • Pipeline Development for Data Quality Control:
  • Design and implement an automated pipeline to perform QC on cell type annotation in query data after the label transfer step. This pipeline will systematically evaluate the accuracy and compatibility of transferred annotations, ensuring reliable and reproducible results.
  • Comparative Analysis:
  • Estimate the suitability of the query data for projection onto the reference dataset.
  • Generate detailed reports on the comparative analysis.
  • Visualization Tool Development:
  • Create an interactive visualization tool to display QC results.
  • Visualize projected cell type results, including mapping scores and projection scores.
  • Develop UMAP visualizations to show how cell types appear on both de novo UMAP and reference UMAP.

FAQs

What is the duration of the internship?

The internship is for the Summer of 2025.

What kind of projects will I be working on during this internship?

You will be working on developing a robust pipeline for data quality control, conducting comparative analysis of query data with reference data, and creating a visualization tool for QC results and projected cell type results.

What qualifications are required for this internship?

The qualifications include proficiency in R programming, familiarity with single-cell RNA sequencing data analysis methods, experience with data visualization libraries like ggplot2 and Plotly, and strong analytical, problem-solving, and communication skills.

Is prior experience in computational biology necessary for the internship?

While prior experience in computational biology is beneficial, it is not explicitly stated as a requirement; however, familiarity with bioinformatics tools used for single-cell analysis is important.

Will I be able to work independently as well as part of a team?

Yes, the ability to work independently and collaboratively as part of a team is a key requirement for this internship.

What is the hourly pay for this internship?

The starting compensation for this internship ranges from $35.00 to $43.00 per hour, depending on demonstrated experience and education level.

Are there any specific tools or libraries that I should be familiar with?

Yes, you should be familiar with data visualization libraries such as ggplot2 and Plotly, as well as bioinformatics tools for single-cell analysis.

What is the significance of the CAR-T cell atlas project mentioned in the job description?

The CAR-T cell atlas project aims to provide a detailed understanding of CAR-T cell phenotypes and their roles within transduced T-cell populations, enhancing the accuracy and reproducibility of cell type annotations.

Are there opportunities for growth and professional development during the internship?

Yes, Bristol Myers Squibb offers opportunities for growth and professional development, promoting a culture that supports employees in pursuing their career goals.

What is the company’s stance on vaccination for COVID-19?

BMS strongly recommends that all employees be fully vaccinated for COVID-19 and keep up to date with COVID-19 boosters.

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Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.