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Postdoctoral Fellow - Human Genetics, McCarthy Lab

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Genentech

3mo ago

  • Job
    Full-time
    Entry Level
  • Research & Development
    Science
  • San Francisco

AI generated summary

  • You have a Ph.D. in Computational Biology or related field with strong expertise in common disease genetics, statistical genetics, and large-scale genetic data analysis. Proficiency in R/Python and excellent communication skills are a must. Be independent, motivated, collaborative, and quick to learn in a fast-paced scientific environment.
  • You will analyze internal and external human genetic data, collaborate with team members, present findings at conferences, and publish high impact research in precision medicine.

Requirements

  • Who You Are:
  • Ph.D. in Computational Biology, Bioinformatics, Human Genetics or related field
  • Strong expertise in common disease genetics (GWAS, polygenic scores) and statistical genetics
  • Proven experience with applying standard pipelines for the analysis of large-scale genetic data sets
  • Demonstrated proficiency with R or Python
  • Demonstrated ability to effectively communicate about complex genetic and statistical questions to both technical and non-technical audiences
  • Preferred:
  • Independent, highly motivated, and highly collaborative with the ability to work together with multi-disciplinary teams of computational and laboratory biologists
  • Enthusiastic about working in a scientific environment, especially one that is related to drug discovery and development
  • Quick learner, is curious about new areas and the opportunity to build expertise, and courageously and creatively take initiative to see your ideas implemented
  • Able to perform at a high level in a fast changing and demanding environment

Responsibilities

  • While this position is primarily computational, the project is highly collaborative, with regular interactions across the organization.
  • You will have the opportunity to work closely with computational colleagues to access and analyze both internal data (eg from our trials and genomic studies on human samples and cellular models ) and from external data sets (eg FinnGen, UKBiobank and other biobanks) to address these questions.
  • You will also have the opportunity for wider interactions, for example with colleagues in clinical development at Genentech, and with researchers in academia and in other companies who have interests in some of these questions (for example through our precompetitive involvement in FinnGen, ICDA and Open Targets).
  • Scientific insights resulting from this research are expected to be presented at external scientific conferences and published in high impact journals.
  • This is an excellent postdoctoral opportunity for someone who is keen to contribute to our understanding of how human genetics (and genomics) can provide the evidence that drives the precision medicine of the future.
  • The research areas covered by this opportunity are topical, of high relevance to Genentech and pharma in general and designed to deliver insights that will bring benefits to patients.

FAQs

What type of research will the Postdoctoral Fellow be involved in within the Human Genetics department at Genentech?

The Postdoctoral Fellow will be involved in research related to studying the application of human genetics in drug discovery, including questions on disease risk, disease progression, clinical trial design, gene perturbation impacts, and leveraging human genetics with single-cell genomics.

What are some key questions that the Postdoctoral Fellow will be addressing in their research?

The Postdoctoral Fellow will address questions such as how disease risk relates to disease progression, how genetics can be used to design smarter clinical trials, strategies for mapping gene perturbation impacts, and leveraging human genetics with single-cell genomics to understand disease biology.

What type of data will the Postdoctoral Fellow have access to within Genentech for their research?

The Postdoctoral Fellow will have access to a wealth of data within Genentech that will enable them to address critical questions related to human genetics in drug discovery, including omics biomarkers, gene perturbation impacts, and single-cell genomics data.

What are some potential research topics that the Postdoctoral Fellow may focus on during their time in the McCarthy Lab?

The Postdoctoral Fellow may focus on research topics related to disease risk, disease progression, clinical trial design, gene perturbation impacts, and leveraging human genetics with single-cell genomics to understand disease biology while working in the McCarthy Lab.

Genentech

Science & Healthcare
Industry
10,001+
Employees
1976
Founded Year

Mission & Purpose

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