Principal Scientist, Discovery BioSciences Oncology

Bristol Myers Squibb

10d ago

Job
Full-time
Mid & Senior Level
Science
Research & Development
Cambridge

AI generated summary

You need extensive experience in oncology biotherapeutics, strong biology skills, gene perturbation methods, project management, and excellent communication abilities. A Ph.D. is preferred.
You will discover oncology biotherapeutic targets, manage teams, strategize concepts, use cellular and molecular techniques, and analyze genetic datasets while collaborating across functions.

Requirements

* Will be responsible for the discovery of next-generation oncology biotherapeutic targets (eg. ADCs, multispecifics, and TCEs) utilizing molecular biology and genome engineering techniques in disease relevant pre-clinical models. The role requires extensive knowledge in how to functionally interrogate biotherapeutics-based mechanisms and modalities including screen conceptualization, design, and execution.
* Effective management skills with a track record of leading effective teams
* Proven ability to strategize, develop, and articulate concepts
* Work across teams, externally interface, with good communication skills
* Strong biology skills with experience using a wide range of cellular and molecular biology techniques, cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning techniques, western blotting, immunoprecipitation, ELISA
* Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown and CRISPR-mediated genome editing) and/or variant screening (deep mutational scanning, base-editing). Experience with ex vivo pharmacology including model generation and optimization is strongly preferred.
* Excellent interpersonal skills with the ability to work in a matrixed environment, interacting with colleagues across functions including translational research, in vitro pharmacology, and drug discovery.
* Ability to interface with computational biologists and AI/ML experts to deploy appropriate analyses methodologies is required
* An ability to mine large-scale genetic screen datasets using desktop tools/interfaces, AI integration, and public databases (CBIO, DepMap, TCGA, CCLE, Genepattern etc.) for target hypothesis generation is strongly desired.
* Proficiency in utilizing software such as Benchling, GraphPad, FlowJo, Microsoft Office, Spotfire, JIRA, Confluence etc. for experimental design, data analyses, tracking, and figure generation is highly desired.
* Bachelor's Degree
* 8+ years of academic and / or industry experience
* Master's Degree
* 6+ years of academic and / or industry experience
* Ph.D. or equivalent advanced degree in the Life Sciences
* 4+ years of academic and / or industry experience
* PhD with 4+ years of academic/industry experience in Oncology, with background in cancer immunology and/or exploration of tumor extrinsic mechanisms is strongly preferred.
* Experienced in the design and development of cell-based viability and reporter assays using various technology platforms, especially gene perturbation to assess viability, imaging, and signaling pathway phenotypes in organoid or tumoroid, and 2D cultures.
* Experience developing molecular biology assays, cell culture, and analyses of protein and DNA/RNA samples using a variety of methodologies including but not limited to vector cloning, flow cytometry, RNAi, CRISPR-Cas, Cas activity assays (reporter and genomics readouts), qPCR, ex-vivo culturing, co-culture assays, functional and imaging-based readouts, lentiviral production and transduction, electroporation.
* Effectively troubleshooting skills when optimizing assays and when developing innovative methodologies.
* Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
* Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.
* Excellent oral and written communication skills. Ability to communicate and discuss data with peers and supervisors.
* Ability to work alongside colleagues in a team environment.
* Exceptional organizational skills and meticulous attention to detail
* Strong problem-solving skills and understanding of relevant scientific principles.

Responsibilities

Will be responsible for the discovery of next-generation oncology biotherapeutic targets (eg. ADCs, multispecifics, and TCEs) utilizing molecular biology and genome engineering techniques in disease relevant pre-clinical models. The role requires extensive knowledge in how to functionally interrogate biotherapeutics-based mechanisms and modalities including screen conceptualization, design, and execution.
Effective management skills with a track record of leading effective teams
Proven ability to strategize, develop, and articulate concepts
Work across teams, externally interface, with good communication skills
Strong biology skills with experience using a wide range of cellular and molecular biology techniques, cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning techniques, western blotting, immunoprecipitation, ELISA
Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown and CRISPR-mediated genome editing) and/or variant screening (deep mutational scanning, base-editing). Experience with ex vivo pharmacology including model generation and optimization is strongly preferred.
Excellent interpersonal skills with the ability to work in a matrixed environment, interacting with colleagues across functions including translational research, in vitro pharmacology, and drug discovery.
Ability to interface with computational biologists and AI/ML experts to deploy appropriate analyses methodologies is required
An ability to mine large-scale genetic screen datasets using desktop tools/interfaces, AI integration, and public databases (CBIO, DepMap, TCGA, CCLE, Genepattern etc.) for target hypothesis generation is strongly desired.
Proficiency in utilizing software such as Benchling, GraphPad, FlowJo, Microsoft Office, Spotfire, JIRA, Confluence etc. for experimental design, data analyses, tracking, and figure generation is highly desired.

FAQs

What kind of work environment does Bristol Myers Squibb promote?

Bristol Myers Squibb promotes a balance and flexible work environment with a wide variety of competitive benefits and resources for employees to pursue their personal and professional goals.

What is the main focus of the Oncology Thematic Research Center at BMS?

The main focus of the Oncology Thematic Research Center at BMS is the discovery and development of novel oncology therapeutics, particularly targeting tumors that are refractory to current therapies.

What qualifications are required for the Principal Scientist role?

Candidates must have a Bachelor's Degree with 8+ years of experience, a Master's Degree with 6+ years of experience, or a Ph.D. with 4+ years of academic or industry experience in Life Sciences.

What are the preferred qualifications for this position?

Preferred qualifications include a Ph.D. with 4+ years of experience in Oncology, experience in cancer immunology, and expertise in designing and developing cell-based viability and reporter assays.

What types of techniques will the Principal Scientist be expected to utilize?

The Principal Scientist will utilize molecular biology and genome engineering techniques, including CRISPR-mediated genome editing and various cellular and molecular biology methods for functional interrogation of biotherapeutics.

Will there be opportunities for collaboration in this role?

Yes, the role requires effective collaboration with colleagues in Discovery Oncology and across the BMS enterprise, including Drug Discovery, Translational Research, Informatics, and Predictive Sciences.

Is prior experience in managing teams necessary for this role?

Yes, effective management skills with a track record of leading teams are important for the Principal Scientist role.

What software proficiency is desired for applicants?

Proficiency in utilizing software such as Benchling, GraphPad, FlowJo, Microsoft Office, Spotfire, JIRA, and Confluence for experimental design, data analyses, and figure generation is highly desired.

What is the organization’s stance on COVID-19 vaccinations?

BMS strongly recommends that all employees be fully vaccinated for Covid-19 and stay up to date with Covid-19 boosters.

Does BMS provide accommodations for individuals with disabilities?

Yes, BMS is dedicated to supporting individuals with disabilities through a transparent recruitment process and reasonable workplace accommodations.

Bristol Myers Squibb

Manufacturing & Electronics

Industry

10,001+

Employees

Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.