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Senior Scientist, Protein Sciences

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Bristol Myers Squibb

23d ago

  • Job
    Full-time
    Junior, Mid & Senior Level
  • Science
    Research & Development
  • San Diego

AI generated summary

  • You need a relevant degree (Bachelor's, Master's, or PhD) with extensive lab experience, strong organizational and communication skills, and knowledge of protein analysis and purification techniques.
  • You will oversee protein production projects, optimize antibody methods, design purification processes, collaborate with teams, conduct analytical tasks, and manage supplies in a tidy lab environment.

Requirements

  • Bachelor's Degree with 7+ years of academic or industry experience
  • or
  • Master's Degree with 5+ years of academic or industry experience
  • or
  • PhD with 2+ years of academic or industry experience
  • Bachelor's Degree with 7+ years of academic or industry experience
  • Bioengineering, Biochemistry, Molecular Biology or related discipline.
  • Extensive hands-on experience with aseptic technique, cell culture, transient and stable recombinant protein production and protein purification.
  • Antibody/protein analysis and characterization including, but not limited to SDS-PAGE, A280, CE-SDS, cIEF, AnSEC, AnHIC, Endotoxin.
  • Exceptional organizational skills and attention to detail.
  • Strong written and oral communication skills are essential.
  • Excellent time management skills and multi-tasking capabilities.
  • Automated liquid handling using the Lynx.
  • Sample inventory management.
  • Experience and knowledge of protein and antibody sequences, antibody databases and data management systems, and ELN.
  • Bispecific antibody purification is desired.
  • Must be very detail-oriented and organized, with excellent time-management and multitasking skills.
  • Have outstanding analytic and problem-solving abilities.
  • Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure.
  • Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team.

Responsibilities

  • Execute multiple and concurrent protein production projects to enable downstream R&D activities. Productions will utilize several platforms, including transient Expi293, ExpiCHO, and stable CHO expression.
  • Possess a detailed understanding of recombinant standard and alternative (bi-/multi-specific) antibody production methods and expression optimization.
  • Demonstrate a track record of initiative, creativity, organization, and independent performance at a high level combined with attention to detail and adherence to timelines/deliverables, and documentation.
  • Participate on project teams to discover, optimize, and manufacture antibody-based biologics, and should be highly effective in collaborating with internal and external team members and CRO's.
  • Special emphasis will be placed on automated antibody purification, which will involve working with Cytiva AKTA (Pure/Avant) and Unicorn software.
  • The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design.
  • Mono and bispecific antibody purification concentrating supernatants, preparation and packing of chromatography columns, and conducting endotoxin free chromatography, including operating preparative and analytical chromatography systems.
  • Deep understanding of the principals of purification; CEIX, HIC, SEC, Affinity, Multi-modal, AEIX and how to apply them to complex antibody modalities.
  • Analytical characterization Endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (anHIC, anSEC), Capillary electrophoresis (CE-SDS and cIEF)
  • Storing, inventorying, and ordering department supplies and chemicals and preparing chemical solutions according to department procedures, specifications, or supervisory instructions.
  • Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
  • Will maintain a neat, clean, and orderly work environment.
  • Experience in external partnership management, due diligence for technology evaluation, project leadership and matrix management are a plus.

FAQs

What is the job title for this position?

The job title for this position is Senior Scientist, Protein Sciences.

What are the primary responsibilities of a Senior Scientist in Protein Sciences at Bristol Myers Squibb?

The primary responsibilities include executing protein production projects, optimizing recombinant antibody production methods, collaborating with cross-functional teams, designing purification methods, conducting analytical characterization, and maintaining a clean work environment.

What qualifications are required for this position?

The position requires a Bachelor's Degree with 7+ years, a Master's Degree with 5+ years, or a PhD with 2+ years of academic or industry experience in relevant fields.

What type of experience is preferred for applicants?

Preferred qualifications include extensive experience with protein expression and purification, understanding of bispecific antibody purification, and proficiency in analytical techniques such as SDS-PAGE, HPLC, and Capillary electrophoresis.

Will I have the opportunity to collaborate with external partners?

Yes, experience in external partnership management and collaboration with internal and external teams is desired for this role.

What kind of work environment does Bristol Myers Squibb offer?

Bristol Myers Squibb offers a supportive and collaborative work environment, emphasizing balance and flexibility, with a variety of competitive benefits and opportunities for personal and professional growth.

Are there any specific technical skills required for this position?

Yes, candidates should have hands-on experience with aseptic techniques, cell culture, automated liquid handling, and analytical characterization of proteins and antibodies.

Is experience in bispecific antibody purification necessary?

While experience in bispecific antibody purification is desired, it is not strictly necessary; however, a solid foundation in protein purification techniques is essential.

Does the role require onsite work?

Yes, this position is listed as site-by-design, which may require at least 50% onsite presence to facilitate collaboration and productivity.

How does Bristol Myers Squibb support employees' well-being?

Bristol Myers Squibb is dedicated to employee well-being by recommending vaccinations for Covid-19, offering a transparent recruitment process, and providing reasonable accommodations for individuals with disabilities.

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Bristol Myers Squibb

Manufacturing & Electronics
Industry
10,001+
Employees

Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.