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Principal Scientist, Translational - Biology

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Bristol Myers Squibb

17d ago

  • Job
    Full-time
    Senior Level
  • Research & Development
    Healthcare
  • San Diego

AI generated summary

  • You need a PhD in a relevant field, 5+ years in translational oncology, experience with targeted therapies, data analysis skills, project management, and strong communication abilities.
  • You will conduct IHC analysis, validate drug targets, lead translational strategies, optimize in vivo models, and analyze data to inform clinical trials and biomarker integration.

Requirements

  • PhD in cancer biology, molecular/cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development.
  • 5+ years of translational oncology experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
  • Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.
  • Understanding of translational research principles and the ability to apply basic research findings to clinical settings.
  • Familiarity with clinical trial design, patient stratification, and biomarker discovery/validation in the context of disease mechanisms and therapeutic interventions.
  • Proficiency in data analysis techniques, including statistical methods, bioinformatics, and interpretation of large datasets (e.g., genomics, proteomics).
  • Ability to design and execute experiments, including preclinical model development (e.g., cell lines, animal models, patient-derived models), to investigate disease mechanisms and evaluate therapeutic interventions.
  • Experience in managing research projects, coordinating timelines, and prioritizing tasks to achieve project goals effectively.
  • Understanding of regulatory requirements and guidelines relevant to translational research, clinical trials, and drug development processes.
  • Creativity and adaptability to explore new research methodologies, technologies, and approaches that enhance translational research outcomes.
  • Ability to work collaboratively with clinicians, researchers, bioinformaticians, and other stakeholders to integrate diverse perspectives and advance translational research goals.
  • Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
  • Strong interpersonal, organizational and communication skills.
  • Prior experience as a project leader or functional leader on interdisciplinary team is critical.
  • Ability to work with radioisotopes with strict adherence to radiation safety protocols.
  • Ability to successfully establish and manage external collaborations including CROs and academic and industrial partnerships.

Responsibilities

  • Conduct immunohistochemistry (IHC) analysis to evaluate new targets identified by the project teams. Interpret and present IHC data to guide decision-making on target selection and validation.
  • Utilize molecular and genetic tools to identify and validate anchor indications for novel therapies. Analyze clinical and preclinical data to support the selection of lead indications.
  • In partnership with a cross functional team leader, provide strategic and operational translational leadership for project teams on specific targets.
  • Contribute to the development of translational research strategies aligned with therapeutic goals.
  • Lead efforts to develop and execute strategies for generating data in relevant models, discover and validate biomarkers that predict patient response to therapies, to inform clinical trial designs.
  • Develop/optimize and utilize preclinical in vivo models that mimic human cancer biology to evaluate drug efficacy, mechanism of action, and resistance mechanisms.
  • Integrate biomarker findings into clinical development plans and regulatory submissions.
  • Investigate mechanisms of radiosensitivity and develop tools and models to predict response to radiotherapy and identify potential biomarkers.
  • Investigate resistance mechanisms and propose strategies to overcome resistance through rational combinations.
  • Author/review study reports and regulatory documentation, scientific presentations and publications and manage external research collaborations.

FAQs

What is the main focus of the Principal Scientist, Translational - Biology position?

The main focus is to bridge laboratory research with clinical applications to advance novel Radiopharmaceutical Oncology therapies, translating scientific findings into actionable insights for clinical development strategies.

Where is this position located?

This is an onsite position located at RayzeBio's office in San Diego, CA.

What educational qualifications are required for this role?

A PhD in cancer biology, molecular/cell biology, pharmacology, or a related field is required, along with a deep understanding of cancer biology and experience in oncology drug development.

How many years of experience in translational oncology are required for this position?

At least 5 years of translational oncology experience in pharmaceutical or biotech R&D environments is required.

What skills are essential for this role?

Essential skills include understanding translational research principles, proficiency in data analysis techniques, the ability to design and execute preclinical experiments, and strong interpersonal and communication skills.

Will the position involve working with radioactive isotopes?

Yes, the role requires an ability and willingness to work with radioactive isotopes while adhering to strict radiation safety protocols.

What responsibilities will be included in this role?

Responsibilities include conducting immunohistochemistry analysis, validating indications for novel therapies, leading translational research strategies, and investigating mechanisms of radiosensitivity and resistance.

Is prior experience in managing research projects important for this role?

Yes, prior experience in managing research projects, coordinating timelines, and prioritizing tasks to achieve project goals effectively is critical.

What is the starting compensation range for this position?

The starting compensation for this job is in the range of $141,034 to $190,811, plus incentive cash and stock opportunities based on eligibility.

Are there opportunities for growth and professional development in this position?

Yes, there are opportunities to grow and thrive through unique work experiences and by collaborating with high-achieving teams rich in diversity.

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Bristol Myers Squibb

Manufacturing & Electronics
Industry
10,001+
Employees

Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.